Autologous Prp With And Without Calcium Sulphate ß- Hemihydrate In Treatment Of Periodontal Osseous Defects: A Randomised Clinical Trial


Last Modified: December 7, 2023


Background: Platelet Rich Plasma (PRP) is an autologous source of concentration of growth factors found in platelets, which on degranulation release various growth factors that play a vital role in healing. The objective of the present study was to assess the efficacy of Autologous Platelet Rich Plasma with and without Calcium Sulphate ß- Hemihydrate in resolution of osseous defects.

Method: A total of 100 subjects in the age group of 30 to 50 years, diagnosed with chronic

periodontitis, with bilateral osseous defects,probingpocket depth > 6 mm and osseous defect > 3 mm as observed on clinical and radiographic examination (intraoral periapical radiograph). In one site Group – A (test group), calcium sulphate ß – hemihydrate with autologous platelet rich plasma was placed in the defect, in contralateral site Group – B (control group) only calcium sulphate ß- hemihydrate was placed in the osseous defect. 

Results: Un-paired t- test was used for comparing the two sets of data at baseline for all parameters between Group – A and Group- B, and all the parameters were found to be statistically insignificant (p > 0.05). The changes in each variable did not follow normal distribution, thus change in each variable was analyzed using a non-parametric test (Mann-Whitney test). Both the groups exhibited clinical improvement in all parameters at the end of the study except for resolution of osseous defects. The resolution of osseous defect (Osseous gain) was higher in Group – A subjects, as compared to Group – B (P < 0.05).

Conclusion: The percentage of resolution of osseous defects (Osseous gain) was higher in Group – A (53.79%) as compared to Group – B (46.02%).

Leave a Reply