Effect Of The Paired Related Homeobox Gene On Mandibular Size: A Case-Control Study
Objective: To evaluate the relationship between mandibular size and polymorphisms of the paired related homeobox-1 (PRX-1) gene in selected human subjects.
Materials and Methods: The study was conducted on 20 individuals subdivided into two groups of 10 individuals each; Group A- Orthognathic individuals and Group B- Patients with mandibular retrognathia. Venous blood samples were collected and after DNA extraction, amplification of the extract was done using PCR followed by sequencing and analysis for polymorphisms at the selected site rs387906667 as referenced from the National Centre for Biotechnology Information (NCBI) database.
Results: Analysis of the PRX-1 gene revealed no change at SNP rs387906667 between Groups A and B. Thymine remained unchanged in the homozygous and heterozygous forms for both the groups. Chromatograms of each of the samples displayed no change in the base pair at the concerned site corresponding to the SNP listed in the NCBI database. Conclusion: For the selected site (SNP rs387906667), no demonstrable correlation was found between mandibular size at nucleotide polymorphism within the Paired Related Homeobox-1 gene.